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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

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If that translates to humans, it could partially explain why some people report that DSIP helps most during periods of high psychological stress, when cortisol disruption of sleep architecture is most pronounced

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